Latest News About Orphines

Updated 2026-05-06 22:03

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News - Orphagen Pharmaceuticals

Funding to support preclinical development of Orphagen’s lead IBD candidate, OR-812, a first-in-class, small molecule inhibitor of the retinoic acid receptor alpha (RARα) SAN DIEGO--(BUSINESS WIRE)--Orphagen Pharmaceuticals, Inc., a biotech company pioneering the... The Cancer Prevention & Research Institute of Texas (CPRIT) announced today that it plans to award Orphagen a $10.2 M product development grant over three years to partially fund the final steps towards IND filing and a Phase 1...

www.orphagen.com

What Are Orphines?

One of the newest and most concerning orphines is N-propionitrile chlorphine. It was first detected in mid-2024 by the Center for Forensic Science Research and Education (CFSRE). Lab studies show it is about 10 times stronger than fentanyl. Since mid-2025, it has been found more often in fatal overdoses. … The data, coming from cases in nine states in the U.S. and 3 Canadian provinces, is alarming.^^ 25 fatal overdoses tested at CFSRE contained N-propionitrile chlorphine. Most occurred in late...

drugfree.org