Miguel Díaz-Canel addressed crowds in Havana the US is trying to destroy Cuba’s political system.
He said the US seeks complete control over the nation.
Díaz-Canel called American policies a case of political genocide during July 26 events.
He emphasised this is a menace to the country's sovereignty.
Raúl Castro did not attend from the largest rally.
Tensions remain high because of sanctions and US political pressure.