Helen Mirren stars as Patricia Highsmith in the new film A Talent for Murder, helmed by Anton Corbijn. Her performance has been described as viperous and spiky. Mirren has called Highsmith the most difficult real person she has ever portrayed, noting her abrasive nature.

Both Mirren and Brosnan defended the actor Tom Hardy amid reports of conflict during the filming of MobLand. She spoke about the role at TIFF.