USC-Oregon Matchup: A Week 4 Showcase

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By Robert Anderson • Updated Sep 27, 2026 at 00:50

College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 4 - CBS Sports — USC-Oregon Matchup: A Week 4 Showcase

Week 4 of college football features a series of notable matchups, such as the Michigan-Iowa game and the Oregon-USC showdown. This week is noted for having the most ranked contests since 2023. Predictions and betting lines are available for the top 20 games. Live updates, schedules, and scores are tracked on NCAA.com. Donald Trump was present at a game with a plan to protect communications. Live broadcasts are available on SiriusXM and local stations.

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